Memory Depotentiation at the Synapse

This image generalizes the electrochemical steps involved in memory depotentiation at the synapse between neurons. A stimulus activates NMDAR, which then permit calcium entry into the cell. As the cell depolarizes, VGCC activates and allows more calcium to flow into the cell. This intracellular calcium-oscillation mobilizes proteins that will eventually cause the cell to degrade the AMPA receptors by means of endocytosis.

*This is a variation of an image I created for the article “Harnessing Electroceuticals to Treat Disorders Arising from Traumatic Stress: Theoretical Considerations Using a Psychosensory Model” in “Explore: The Journal of Science and Healing”.


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